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Results HIF1 and HIF2 KO NSCLC cells are metabolically rewired towards ser/gly synthesis To investigate the metabolic differences between HIF1 and HIF2 under normoxic conditions, we used NCI-H1299 lung cancer cells with HIF loss-of-function mutations that were previously generated in our group, i.e., HIF1 KO and HIF2 KO, using HIF wild type (WT) as control [34]