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The reasons for this recycling are incompletely understood, though they may be related to a hexose-6-phosphate dehydrogenase reported to reside within ER of cancer cells, relying on glucose-6-phosphate provision 89,90

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For example, in response to hyperglycemia, histone methyltransferase Setd7 protein accumulates in the nucleus of ECs, which promotes Il - 8 , Icam1 , and Cxcl2 expression in an H3K4me1-dependent manner, and inhibits Hmox1 expression in an H3K4me1-independent fashion to regulate hyperglycemic memory [115]

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doi: 10.1128/IAI.70.8.4099-4105.2002 [DOI] [PMC free article] [PubMed] [Google Scholar] [118].Jones MB, Peterson SN, Benn R, et al

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