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Description

The N-terminus of activated ERM proteins bind to a motif between the transmembrane region and the ankyrin-binding site of CD44, and the carboxyl terminus binds to filamentous actin (F-actin), thus linking CD44 to the actin cytoskeleton [107]

(1) This is allowed by its structure as it is the shortest functional analog of endogenous GHRH with a C-terminal amidation that may help stabilize the molecule