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Exploring the mechanism of adjuvant treatment of glioblastoma using temozolomide and metformin

In fibroblasts, the mannose-6-phosphate receptor pathway mediated uptake and delivery of -Gal A to the lysosomes, whereas, at least in the applied in vitro system, the mannose-6-phosphate receptor pathway did not mediate lysosomal delivery of -Gal A into endothelial cells

The study quantified cytokines, neurotransmitters, oxidative stress markers and detoxification enzymes using ELISA-based assays, revealing that VPA exposure disrupted glutathione balance, increased IL-6, CYP450 and glutamate, and reduced serotonin and IFN-, while curcumin partially restored these alterations ( Furthermore, Yang and Bhandari employed a PPA-induced rat model of autism, using male-only Sprague-Dawley rats that received intracerebroventricular infusions of 1M PPA

Efficacy and safety of ocrelizumab in active proliferative lupus nephritis: results from a randomized, double-blind, phase III study

People who are prone to getting sick can benefit from regular IV therapy to stay healthy year-round

Cell 15 , 506519 (2004)