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To ascertain a comprehensive role of the UPR in cystine uptake inhibition-induced ferroptosis, we examined the status of the three canonical UPR pathways: (1) IRE1-XBP1s, (2) PERK-ATF4-eIF2 and (3) ATF6 in both MDA-MB-231 and Panc-1 cells upon erastin treatment or cystine starvation

2014;4(9):a019778

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In a key study of 1000 drug-like small molecules, less than 10% accumulated to concentrations greater than 50% of that present in the medium [12]

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