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BOX1: Complexity of genetic alterations and metabolism in PDAC In addition to the most frequent oncogenic somatic mutation KRAS , a high percentage of patients carry inactivating somatic mutations in the tumor suppressors cyclin-dependent kinase inhibitor 2 A ( CDKN2A ), tumor protein 53 ( TP53 ), and SMAD family member 4 ( SMAD4 ) [113,114,115], reinforcing their roles during PanIN-to-PDAC [116]

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doi: 10.1016/j.yrtph.2006.06.004, 51

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Characterization of the Arabidopsis metallothionein gene family: tissue-specific expression and induction during senescence and in response to copper

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[DOI] [PubMed] [Google Scholar] 239.Tang J., Wingerchuk D.M., Crum B.A., Rubin D.I., Demaerschalk B.M

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