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Both genetic and non-genetic forms of DCM share pathways with hypertrophic cardiomyopathy, particularly in terms of mechanisms leading to ferroptosis (136)

Andreeff M

Hydrogen peroxide stimulates tetrahydrobiopterin synthesis through the induction of GTP-cyclohydrolase I and increases nitric oxide synthase activity in vascular endothelial cells

47 Evaluation for Systemic Manifestations Once a DM diagnosis is made, it is critical to assess and follow patients for presence/development of visceral organ involvement and malignancy, as these contribute greatly to morbidity and mortality

This dysregulation results in changes to the hormones that they secrete and causes conditions such as leptin resistance

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