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found that quercetin indirectly prevents inflammation by enhancing peroxisome proliferator-activated receptor activity, thereby opposing NF-B or AP-1 mediated transcription of inflammatory genes, collectively obstructing the TNF--mediated inflammatory cascade and reducing inflammation damage from radiation therapy 38

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Thirty-three point mutations of the CBS gene, which is located on chromosome 21, have been identified

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Additionally, B5 derivatives decrease tumor necrosis factor-alpha (TNF-) levels and reduce oxidative stress in patients with endometriosis (Karapinar et al., 2017)