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The most significant changed plasma metabolites in MS-affected Chinese patients were amino acid, lipid and their derivatives, of which representative differentially abundant metabolites such as L-glutamic acid, L-leucine and L-isoleucine, as well as sphingosine 1-phosphate and sphinganine 1-phosphate, were also identified in Caucasian populations with MS (26, 44, 107)

Akkermansia muciniphila is a novel probiotic that can increase the abundance of Firmicutes, restore the gut microbiota structure in DSS-induced colitis mice, reduce inflammation levels through microbial-host interaction, and protect the mucosal barrier[142 ]

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