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Description

Rose et al 2023 demonstrated that certain chemotherapeutic drugs such as talazoparib, camptothecin and etoposide binds and traps proteins (PARP and topoisomerases I and II, respectively) on DNA strands, resulting in DNA damage and double-strand breaks

Discussion In this study, we fabricated a hydrogen-bond crosslinked and ultra-durable hydrogel (PTK hydrogel) loaded with TA and KGN for cell-free cartilage regeneration