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PubMed Central Schollhammer M, Brenaut E, Menard-Andivot N, Pillette-Delarue M, Zagnoli A, Chassain-Le Lay M, Sassolas B, Jouan N, Le Ru Y, Abasq-Thomas C, Greco M, Penven K, Roguedas-Contios AM, Dupr-Goetghebeur D, Gouedard C, Misery L, Le Gal G

Further, our motif discovery analyses support the hypothesis that epigenetic remodelling in the USCs occurs primarily at AP-1-associated DARs in response to a self-limiting acute infection (resolved-accessible DARs), but that severe acute infection leading to chronic infection and inflammation (sensitized-accessible DARs) induces epigenetic remodelling not only at AP-1-associated DARs, but also at additional TF-associated DARs, such as those with Klf and Sox family motif sites

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PF showed the strongest anti-convulsive effect when initiated before excitotoxic damage occurred