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Advanced experimental techniques, including spatial transcriptome, single-cell (or nuclei) transcriptomics and assay for transposase-accessible chromatin using sequencing, will be instrumental in uncovering the epigenetic and transcriptomic signatures associated with the transformation of astrocytes under neurodegenerative conditions 156

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Bonus- they're also crucial for the regulation of neurotransmitters like serotonin and dopamine, to help lower stress and anxiousness

379 In PGC-1 knockout mouse models, DA neurons exhibit increased sensitivity to the neurotoxin MPTP, potentially due to the lack of PGC-1-mediated induction of antioxidant responses

Another reaction that generates free radicals is the purine metabolism, where xanthine oxidase catalyses the conversion of hypoxanthine to xanthine and subsequently to uric acid, and during its re-oxidation, molecular oxygen is reduced to superoxide [31]