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Studies in rodent models have examined ipamorelin's effects on GH pulse amplitude, IGF-1 elevation, bone mineral density, and body composition parameters

10.1016/j.fbio.2024.105238 24 StehlikS.VargaM.LedinskyM.MiliaievaD.KozakH.SkakalovaV.et al

Jan 22 2002;166(2):213-218

This downregulates small guanosine triphosphatase (GTPase) prenylation (e.g., RhoA activation), which otherwise suppresses eNOS expression and promotes EC inflammation [243,244,245,246]