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The combination approach appears most promising for long-term sustainability

However, ACSL4 is not necessary for all ferroptotic cell death, which means under special circumstances ferroptosis is able to be induced in ACSL4-depleted cells ( Ferroptosis is induced due to lipid peroxidation activated via non-enzyme-dependent (Fenton reaction) and enzyme-dependent processes

The initial investigations aimed to identify components within gastric juice that contribute to the stomach's remarkable ability to protect and repair itself, a concept known as cytoprotection