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The researchers also conducted RNA-sequencing, which apparently pointed to reduced activity of pathways involved in ECMreceptor interaction and focal adhesion, alongside lower levels of key ECM proteins such as fibronectin, tenascin C, laminin, thrombospondin-2, and Hmmr

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For patients co-infected with HIV, Miltefosine has demonstrated potential in Ethiopian trials, though the rise of drug resistance in endemic regions remains a concern (Ritmeijer et al., 2006)

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