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Clinicians in primary care settings are uniquely positioned to help ensure that patients with these types of symptoms, in the absence of other confirmed diagnoses, are screened for major depressive disorder (MDD) and then adequately treated.1 Despite the availability of many new treatments, a number of patients with MDD experience inadequate symptom relief.2 More than half of all patients with depression fail to achieve remission after first-line antidepressant therapy.3,4 This outcome may be especially true for patients with anxious or atypical symptoms or patients who experience recurrent episodes or treatment resistance

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Bupropion increases dopamine activity and POMC neuronal activation, thereby reducing appetite and increasing energy expenditure (54)