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However, even though AAV is non-pathogenic, currently approved AAV gene therapies are limited to a one-time administration due to the typically high immune response achieved on a second dose based on the immunogenicity of the viral protein [169]

(2019) in urine but first detects are reported from De Ruyck et al

In addition, women tend to underestimate the total sleep time and number of arousals they report, which means the problem is almost certainly more serious