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Photoreceptor cells are more prone to oxidation than other cells in the retina and rely on the carotenoids for protection due to their greater oxidative stability

As for chemotherapy, trials have shown that when coupled with Cisplatin, there was a significant reduction in nephrotoxicity in patients with ovarian cancer, as well as a greater tumor response

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While adult studies have had conflicting results regarding the significance of MTX on liver fibrosis/ steatosis, this may be due to a greater degree of metabolic factors in adults