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In a pilot study during 1 month of four patients with Crohns disease the mean serum cobalamin concentration increased significantly after weekly administration of 1500 g of the same formulation

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These effects could lead to suppressing cyclin D1, re-expressing silenced tumour suppressor genes, inhibiting inflammation mediated by NF-B, or downregulating metastatic markers like MMP-2 and MMP-9

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