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HSP27 immune complex activates TLR4/NF-B signaling and increases the level of anti-inflammatory cytokine IL-10 in macrophages

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For instance, SCFAs can inhibit NF-B activation and the secretion of inflammatory cytokines like TNF- in peripheral blood monocytes, neutrophils, and macrophages, thereby mitigating excessive immune responses

Furthermore, the intracellular survival mechanism of the bacterium requires the involvement of each enzyme comprising the H 2 O 2 detoxification system, including GpoA, TpxD, and AhpD