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However, acquired resistance to treatmentwhether chemotherapy or targeted therapyremains the most significant challenge in the management of PDAC [4, 5]

Thse induction mechanism of ferroptosis, necroptosis, and pyroptosis in inflammatory bowel disease, colorectal cancer, and intestinal injury

Interestingly, it has been shown that cisplatin treatment can reduce MGMT activity and expression, which is an explanation for the synergism between TMZ and cisplatin