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Despite unaltered HCV titer, the production of infectious particles was decreased, interestingly more by quercetin treatment than by HSP knockdown, displaying a dose-dependent relationship: at 0.5 M quercetin reduced viral production by 29%, at 5 M by 90%, and at 50 M by nearly 100% (84)

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Glutathione is a tightly regulated intracellular constituent, and is limited in its production by negative feedback inhibition of its own synthesis through the enzyme gamma-glutamylcysteine synthetase, thus greatly minimizing any possibility of overdosage

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Similarly, a small amount of 2-thio N -pyrrole was observed on reaction with glycine generating 2f (5.3%) along with the major product 3-thio N -pyrrole 2f (53.9%) as analyzed by the NMR of the inseparable mixture of 2f and 2f (Fig

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