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J Am Diet Assoc 109:414421 Ito N, Hirose M, Fukushima S, Tsuda H, Shirai T, Tatematsu M (1986) Studies on antioxidants: their carcinogenic and modifying effects on chemical carcinogenesis

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As a SERM the direct antiproliferative effect include decreasing cell number, DNA content and thymidine incorporation

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[4] In contrast, methionine limitation in the diet decreased insulin resistance in rodents and promoted adipose tissue lipolysis and fatty acid oxidation