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403,404 The PHERGain study explored whether it is possible to treat patients with early HER2+ breast cancer with dual antibody therapy alone in both neoadjuvant and adjuvant settings, completely sparing chemotherapy

Proc Nat Acad Sci USA

Poor lung function and poor nutrition may also exacerbate muscle weakness, abnormalities in fluid and electrolyte balance, and depression (GOLD 2011

Metabolomic analysis revealed that VPA -induced abnormal liver function resulted in the accumulation of serum long-chain acylcarnitines (LCACs), and the reduced expression of -FAO relevant genes (Carnitine palmitoyltrans-ferase (CPT)1, CPT2 and Long-chain acyl-CoA dehydrogenase (LCAD)), indicating the disruption of -FAO

This study showed that a subgroup of patients using this innovative de-escalating approach omitting chemotherapy received a pCR response, and around one-third of the patients achieved a promising 3-yeat iDFS from surgery with chemotherapy-free therapy

When consumed in moderate amounts (400 mg or less), caffeine has been found to have protective effects on the brain