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In the era before molecular cloning, when radioligand binding and displacement was the only major tool, spiperone and LSD were shown to label two different 5-HT receptors, and neither of them displaced morphine, leading to naming of the 5-HT 1 , 5-HT 2 and 5-HT 3 receptors, corresponding to high affinity sites from LSD, spiperone and morphine, respectively