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Pharmacokinetics of biological drugs The biological basis of pharmacokinetics General considerations Absorption Absorption from the gut Absorption from other routes Distribution Reversible protein binding Irreversible protein binding Distribution to specific organs Elimination Metabolism Excretion The mathematical basis of pharmacokinetics General considerations Absorption Rate of absorption Extent of absorption Distribution Rate of distribution Extent of distribution Elimination Rate of elimination Extent of elimination Chronic administration Time to reach steady-state Plasma concentration at steady-state Oral administration Loading dose Pharmacokinetics of biological drugs Genetic variation and drug kinetics Pharmacokinetics of biological drugs The type of response experienced by an individual to a particular drug depends on the inherent pharmacological properties of the drug at its site of action

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5FU has previously been demonstrated to have a significant metabolic impact shortly after treatment, rapidly and consistently inhibiting TS 5

121, 879888.10.1104/pp.121.3.879 32 MaughanS

This process is different from other conjugation reactions because glucuronic acid, sulfate and amino acid conjugations take place at nucleophilic centres