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Zou Y, Li H, Graham ET, Deik AA, Eaton JK, Wang W, Sandoval-Gomez G, Clish CB, Doench JG, Schreiber SL

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1-MX is an adenosine receptor antagonist and increases the release and survivability of neurotransmitters

Aging is accompanied by deteriorating proteostasis and altered modification landscapes, which compromise the reversible and dynamic property of LLPS, triggering the formation of aberrant, solid-like aggregates that exacerbate neuronal dysfunction and neurodegeneration