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34 CELL SURFACE-TARGETED MONOCLONAL ANTIBODIES Monoclonal antibodies are drugs directed against specific antigens on cells that cause disease

This means that DNA adducts, which are repaired and appear in the urine, can be used as surrogate biomarkers of DNA damage Citation[119,120]

vii) first- and second-order asymmetric transformationsa technique whereby diastereomers from the racemate equilibrate to yield a preponderance in solution of the diastereomer from the desired enantiomer or where preferential crystallization of the diastereomer from the desired enantiomer perturbs the equilibrium such that eventually in principle all the material is converted to the crystalline diastereomer from the desired enantiomer

Acknowledgments We would like to thank Jiaying Yan for her contribution to section 5.2 during the revision of this paper

In pancreatic cancer, the ACSS2-mediated Zrt- and Irt-like protein 4 (ZIP4) signaling pathway reshapes metabolic activity by increasing the macropinocytosis of cancer cells and is positively associated with a poor prognosis [207]

In addition, AS-IV-based SLN-gel can regulate collagen fiber arrangement and collagen deposition and reduce scar formation