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Clinicians estimate vitamin B12 requirements using values such as: Recommended dietary allowance (RDA): RDArefers Trusted Source National Institutes of Health Office of Dietary Supplements Go to sourceto a daily intake that, on average, is enough to meet the nutritional requirements of almost all people without underlying health conditions

The Medicines and Healthcare products Regulatory Agency (MHRA) in the UK, along with international regulatory bodies, requires extensive stability testing before approving any medication

It matters because a small molecule behaves differently from a peptide in dosing, stability, and how it is studied

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High dose parenteral ascorbate inhibited pancreatic cancer growth and metastasis: mechanisms and a phase I/IIa study