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In C2C12 myotubes and skeletal muscle from obese mice, capsaicin upregulates sarco/endoplasmic reticulum Ca 2+ -ATPases (SERCA1/2) and ryanodine receptors (RYR1/2), thereby activating ATP-consuming Ca 2+ futile cycles that recycle Ca 2+ across the sarcoplasmic reticulum and dissipate energy as heat (13)

J Nutr 123(11):17861793

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The role of macrophage-derived exosomes in liver diseases

Clinical Trials In the study of the antipyretic mechanism of TCM, various models have been developed to simulate the natural fever of experimental animals

[DOI] [PubMed] [Google Scholar] 91.Scholler P., Nevoltris D., de Bundel D., Bossi S., Moreno-Delgado D., Rovira X., Mller T.C., El Moustaine D., Mathieu M., Blanc E., McLean H., Dupuis E., Mathis G., Trinquet E., Daniel H., Valjent E., Baty D., Chames P., Rondard P., Pin J.P