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[Chronic] insomnia is clinically defined by trouble falling or staying asleep for three or more days a week over a three-month period, says Alex Dimitriu, MD, a double board-certified physician in psychiatry and sleep medicine and the founder of Menlo Park Psychiatry & Sleep Medicine

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APE-LNPs containing 5moU-modified FLuc mRNA with C4 to C9 side chains efficiently delivered mRNA to the lungs, spleen, and liver, with organ selectivity depending on the side-chain length [287]