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After consideration of the public comments we received, we are finalizing the proposed APC recalibration changes for the Diagnostics Tests and Related Procedures APC series

The statistical analysis of the lipophilic fraction (Fig 2B and B) generated a weak OPLS-DA model with only limited class separation (with parameters R 2 = 0.56 and Q 2 = 0.28, CV-ANOVA test, P = 0.6), with a single metabolite (glycerophospholipidssphingomyelin) responsible for the class distinction (Figs 2B, B, and C and S3)

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