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Cysteine availability is typically the rate-limiting factor for synthesis, which is why N-acetyl cysteine (NAC), a cysteine donor, is one of the most effective strategies for raising glutathione levels [2][9]

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Moreover, T-follicular helper (Tfh) cells, found in germinal centers and extrafollicular regions, are crucial for generating autoreactive B-cell clones in SLE (69, 70)