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Q: Is this safe for long-term use

38 Studies have demonstrated that ER stress activates the unfolding protein response and the ER-resident cysteine protease, initiating the caspase cascade and amplifying the proapoptotic signal by altering the balance between Bcl-2 and Bax, and inducing caspase-dependent and -independent pathways

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Research protocols vary, with some using cyclic patterns rather than continuous daily use

Flavonoids were quantified using peak areas of A 280nm , A 500nm or selective ion monitoring in positive mode with external calibration curves prepared in the same solvent as the samples