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Research groups are also actively trying to resolve health and environmental concerns related to the use of GO by developing strategies to reduce its toxicity, including coating or functionalizing GO with biocompatible materials and investigating biodegradable GO composites for safer environmental impact

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10.1016/j.aquatox.2006.01.012

Key priorities include doseresponse optimization for acute versus chronic phases, inclusion of biomarkers such as glutathione reductase activity, neuroinflammatory cytokines, and imaging-based lesion metrics, and development of formulations that improve central nervous system bioavailability

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