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The normal range is 0.5% to 2%

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Supplemental doses of vitamin A greater than 10,000 IU (3,000 mcg retinol activity equivalents [RAE]) have been found to be dangerous during the first trimester of pregnancy

Mutational processes of tobacco smoking and APOBEC activity generate protein-truncating mutations in cancer genomes

They are also developing new treatment protocols that integrate MTH1 inhibitors with different therapeutic methods

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