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Schneider, T., Tan, Y., Li, H., Fisher, J

In the synovial fluid of individuals with OA, increased lactate facilitates lactylation of UDP-glucose dehydrogenase (UGDH) at lysine 6, disrupting its interaction with signal transducer and activator of transcription 1 (STAT1), suppressing its enzymatic activity and glycosaminoglycan synthesis, and altering its nuclear-cytoplasmic distribution, activating the MAPK signaling pathway and ultimately contributing to OA progression

10.1016/S0009-2797(97)00149-X

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The metallic compound promotes primordial follicle activation and ameliorates fertility deficits in aged mice

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