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Next, GSH is formed from addition of glycine to - glutamylcysteine by glutathione synthetase (GSS)

[1] This cycle ensures that cells maintain the optimal GSH:GSSG ratio of 10:1 to 100:1, a critical indicator of cellular health

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In contrast, MYCN-amplified cell lines exhibited radioresistance under the same conditions, suggesting that targeting Gln metabolism can be beneficial for the treatment of c-MYC-driven but not MYCN-amplified neuroblastoma [134]