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The search strategy employed Boolean operators (e.g., AND, OR) to combine terms for natural flavonoid metabolites (e.g., quercetin, baicalin, epigallocatechin-3-gallate [EGCG]) with keywords related to AD and its underlying mechanisms, including skin barrier dysfunction, immune dysregulation, chemokine imbalance, pruritogenic signaling, microbial dysbiosis, programmed cell death, oxidative stress, and drug delivery

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Additionally, individuals with a history of certain medical conditions, such as strokes, heart attacks, or blood clotting disorders, are not suitable candidates