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Epigenetic dysregulation of ACE2 and interferon-regulated genes might suggest increased COVID-19 susceptibility and severity in lupus patients

Seminars in Hematology 19, 54

References de Oliveira, S., Rosowski, E

These data indicate that thresholds for the diagnosis of advanced fibrosis in HFE-hemochromatosis are lower than those observed for more overtly inflammatory chronic liver diseases, such as chronic viral hepatitis, alcoholic liver disease, and MAFLD [106]

Di Minno MND, Pezzullo S, Palmieri V, Coppola A, DAngelo A, Sampietro F, Cavalca V, Tremoli E, Di Minno G (2011) Genotype-independent in vivo oxidative stress following a methionine loading test: maximal platelet activation in subjects with early-onset thrombosis

In fact, these downstream effects of ROS production may ultimately be responsible for much of the bactericidal activities of ROS rather than direct damage by ROS themselves (Miralda et al., 2017)