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Recent investigations have further elucidated that histone lactylation augments ALKBH3 expression, while simultaneously attenuating the formation of promyelocytic leukemia protein (PML) condensates, a tumor suppressor, and exacerbating malignant transformation through the removal of m1A methylation in SP100A, thereby facilitating cancer progression (147)

Their findings highlight a crucial MGBA in which intestinal immune modulation directly influences the severity of ischemic brain injury (Benakis et al., 2016)

Molecules 25(15):3383 Kim JY, Jeong HY, Lee HK, Kim S, Hwang BY, Bae K, Seong YH (2012) Neuroprotection of the leaf and stem of Vitis amurensis and their active compounds against ischemic brain damage in rats and excitotoxicity in cultured neurons