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Evidence for or against the use of coffee enemas is mostly anecdotal. (1) On the contrary, there is scientific evidence from a University of Minnesota study proving that palmitic acid increases glutathione levels by 600-700%

[DOI] [PMC free article] [PubMed] [Google Scholar] 67.Kadlec AO, Beyer AM, Ait-Aissa K, Gutterman DD

When Injection Site Reactions Require Provider Guidance Mild localized redness, warmth, or brief burning is expected and typically does not require medical intervention

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Roy, PhD **Updated April 27, 2021 to include current data Analies Dyjak, M.A