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Through this exploration, we aim to illuminate the broader implications of mTOR signaling in cellular function and disease and provide a comprehensive overview of current knowledge and future directions in studying transcriptome plasticity

We conducted a first cross-ancestry genomic study of PSMD in 58,403 participants from 24 population-based cohorts to decipher its genetic underpinnings

Ultimately, this work lays a robust foundation for a transformative therapeutic paradigm in PD, moving us closer to an effective and patient-centric treatment

10.1038/aps.2009.24 53 DoyleK

The analysis also explores the therapeutic potential of targeting critical ferroptosis pathways, including dysregulated iron metabolism, impaired antioxidant defenses, and abnormal lipid peroxidation