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The motif is part of the Sth1 protrusion domain and includes a surface-exposed aromatic tryptophan, as well as negatively charged residues (Supplementary Fig

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When safety of the study participants and technological developments allow, so called biomarkers can be used to collect PD data to understand if the drug reaches the target, binds to the target and exerts its expected pharmacological activity within the dose range tested

Biogenic gold nanoparticles induce cell cycle arrest through oxidative stress and sensitize mitochondrial membranes in A549 lung cancer cells

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This is in accordance with previous findings that an increase in MDA level due to lipid peroxidation is one of the most common markers of cellular oxidative damage under the heat stress 40