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Taken together, these strategies underscore a paradigm shift from static precision oncology toward evolution-informed cancer medicine, in which treatment is continuously adapted to tumor heterogeneity and dynamic resistance trajectories

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Monocyte chemotactic protein (MCP-1, CCL-2), macrophage inflammatory protein-1 (MIP-1, CCL-3) are CC-chemokines, which act as chemoattractants for inflammatory cells like macrophages, lymphocytes

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