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The SURMOUNT trials with tirzepatide demonstrated weight loss exceeding 20% at the highest doses, substantially more than what orforglipron has achieved in Phase 3

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Because of the unknown potential for serious adverse reactions in the breastfed infant due to the possible accumulation of SNAC from breastfeeding and because semaglutide injection can be considered for use during lactation, advise patients that breastfeeding is not recommended during treatment with oral semaglutide tablets

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