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At the same time, reduced IDO activity reduced kynurenine and further weakened peripheral immune tolerance, which played a driving role in the hypothyroidism immune disorder caused by the imbalance of the whole gut microbiota (Clarke et al., 2017)

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On the other hand, Gong et al

(2017) optimized fermentation conditions via response surface methodology and found that critical parameters (e.g., pH 7.79 and enzyme concentration 2.73%) must be precisely matched to strain characteristics to avoid significant reductions in extraction efficiency