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Lancet 355: 12741275

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Apigenin : helps alleviate pre-sleep anxiety, allowing people to quiet their minds, cease anticipation of future events, and transition faster to sleep

Gu H, Zou Y-R, Rajewsky K

prophylaxis for migraine headaches (not effective for acute therapy) Contraindications: hepatic disease or significant dysfunction pregnancy (valproate was upgraded from Category D to Category X in 2013)(FDA Drug Safefy & Availability) Side Effects: Several epidemiologic studies have indicated a higher incidence of & an increased incidence of cardiovascular, orofacial & digital abnormalities in the offspring of mothers who took valproate during pregnancy

It is diagnosed according to the Canadian consensus criteria, at least 6 months after onset when the following symptoms are present: fatigue, post-exertional malaise with a recovery period of at least 24 h, sleep dysfunction, pain, at least two neurological/neurocognitive symptoms and at least two symptoms involving the autonomic, neuroendocrine or immune system [19]