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Here, we have reviewed the evidence supporting the hypothesis that a large number of genes can contribute to platinum resistance either directly or indirectly

The circles denoting each category of PD would intersect, illustrating the shared risk factors between the two types and the distinct risk factors specific to each type

Olsen RH, Kukor JJ, Kaphammer B (1994) A novel toluene-3-monooxygenase pathway cloned from Pseudomonas pickettii PKO1

A., Williams, R

Based on the above, it becomes feasible to enhance the affinity of a stapled peptide with its receptor by experimental validations, such as alanine scanning mutagenesis, isothermal titration calorimetry, and surface plasmon resonance, which can be employed to evaluate the binding affinity of the designed peptide and determine whether the predicted interactions are consistent with experimental observations

Ion channel modulators, specifically those aimed at PIEZO1 and the Gardos channel, provide a method to restore ionic equilibrium, diminish dehydration, and mitigate hemolysis in conditions like hereditary xerocytosis and sickle cell disease (80)