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However, in the IPL, GSH levels were lower during the same condition (sustained cognitive effort), with this effect being stronger in young individuals

OPNAs exert their toxic effects primarily by irreversibly inhibiting acetylcholinesterase (AChE), accumulating acetylcholine at synapses, and causing cholinergic crisis

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Emerging gene-editing technologies, particularly CRISPR/Cas9, now allow for the precise introduction of human disease-associated alleles or even the replacement of zebrafish genes with their human counterparts, creating humanized models that promise far greater fidelity in mimicking human pathology and pharmacological response (Schellens et al., 2022)

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